Endocrine Abstracts

Introdution: Prolactinomas in men are rare and the majority are macroadenomas. Some studies suggest that these tumors in men have higher proliferative activity and aggressiveness indicating gender-specific differences in biological behavior. Dopamine agonists (DA) are considered first-line therapy.Material/methods: Retrospective analysis of male patients diagnosed with prolactinoma between 2005 and 2016. Age at presentation, clinical, hormonal and image ...

Prenatal and postnatal environment can regulate gene expression through multiple epigenetic mechanisms, being DNA methylation among the most relevant. Metabolic and reproductive function may be modified by this mechanism. Sons born to women with PCOS show altered markers of metabolic and reproductive function during childhood and adulthood. However, these functions have not been studied during puberty. The aim of the present study was to assess the global methylation pattern a...

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

Ethanol and laser ablation of benign thyroid nodules is bursting rapidly in clinical practice because of its efficacy, safety and economy. However, these techniques require some manual operator training. In order to facilitate this hands-on training, we propose two homemade, cheap and specific simulators to practice these clinical procedures.Material and methodsTwo models were optimized: Gel-Phantom Coruna VR16 (gelatine a...

Nonadherence to levothyroxine therapy is one cause of persistent hypothyroidism. To distinguish nonadherence from malabsorption, a levothyroxine absorption test (LAT) is sometimes required. The authors report a case of a 60-year-old female patient suffering from hypothyroidism resistant to oral levothyroxine (LT4) substitution after radioiodine therapy for Graves’ disease. Despite the continuous increases of LT4, over 10 years, to a maximum of 1 mg/d...

Introduction: Regional lymph node (LN) metastases have prognostic significance in differentiated thyroid cancer (DTC). Several studies demonstrated that lateral neck LN metastasis, classified as N1b, have a greater impact on overall survival than central LN metastasis. Our study aimed to assess the risk of N1a vs N1b involvement on outcome in patients with differentiated thyroid cancer (DTC), according to the 7th edition of the TNM staging system.Methods...

Introduction: Cystic masses of neck consist of a variety of pathologic entities. The age of presentation and clinical examination narrow down the differential diagnosis. In adults are considered to be malignancies until proven otherwise (thyroid lesions, salivary gland neoplasms, metastatic squamous cell carcinoma and lymphatic malformations such as the cystic lymphangioma. Ultrasound (US) is often used for initial evaluation. Computed tomography (CT) and MRI provides addition...

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

Introduction: Multiple Endocrine Neoplasia type 1 is an underdiagnosed autosomal dominant disorder, with inter and intrafamilial variability without a genotype-phenotype correlation.Case report: A young female (born in 1986) presented with galactorrhea and secondary amenorrhea in 2002, and investigation revealed a prolactinoma. Her brother (born in 1982) presenting gynecomastia and erectile dysfunction at age 21, was also diagnosed with prolactinoma. The...

Introduction: Contradictory associations between sleep disturbances and changes in cortisol levels or unfavourable metabolic conditions like obesity and diabetes mellitus have been observed.The aim of the present study was to examine salivary cortisol in persons with reduced sleep quality and to evaluate the relationship between sleep quality and metabolic parameters.Methods: The Pittsburgh Sleep Quality Index (PQ8I) was used in 15...